Akeso advances AK157D1 B7-H3 ADC into Phase I development on August 21, 2026 AK138D1 Akeso Antibody-Drug Conjugates Cadonilimab CD276 gene Ivonescimab N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide Phase I Clinical Trials Solid Neoplasm therapeutic autologous dendritic cells +