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Alnylam Cuts Amvuttra Sales Guidance as Second-Line Demand Normalizes, Hitting Stock

on July 31, 2026

ALNY Alnylam Amvuttra ATTR-CM Demand (clinical) earnings guidance cut guidance revision Market Normalize (activity) pent-up demand Reaction revenue guidance Sales - occupational activity stock plunge TTR gene

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care cost reduction cost-cutting initiatives cost-effective cost-effectiveness cost-effectiveness ratios cost-reduction cost-saving country-of-origin labeling covalent binding drugs covalent biologics covalent chemistry covalent drug discovery cranial neurosurgery crash craving control credit card fees critical bleeding crizanlizumab crofelemer cross-border cross-border pharma ctDNA-guided therapy curated data curative medicines customer-facing organization customs loophole cut corners cutaneous disease activity cutaneous remission cyclic adenosine-5'-trimetaphosphate cyclobenzaprine cynicism cytarabine/etoposide/methotrexate protocol cytisine daily pills daisy danegaptide dapagliflozin daratumumab daridorexant data bottlenecks data breach data gaps data generation data harmonization data misinterpretation data modernization data package data secrecy data solutions data stewardship data stolen data-driven decisions data-driven health data-driven innovation de novo miniproteins deal activity deal termination death risk reduction debt maturity extension debt obligations debut decade-long safety test deceptive deceptive marketing decision day decision science declaratory judgment defactinib deficiencies degrader degree of relationship - exchange delayed readout delgocitinib delist delivery options demerger demyelination dencatistat depression drug deprioritization deputy commissioner deruxtecan-nxki deucrictibant XR developmental restoration device regulation dexmedetomidine diabetes drugs diagnostic kit diagnostics industry diazoxide choline difficult-to-treat psoriasis digestive health startup digital coaching digital dermatology digital enablement digital endpoints digital health ecosystem digital health records digital health regulation digital health screener digital infrastructure digital marketing digital medicine digital microfluidics digital pathology prognostic test digital quality systems digital solutions digital therapeutic digital tools digital twin diluted cardiomyopathy dimethylethylsilylimidazole direct-to-consumer ( DTC ) direct-to-employer direct-to-patient model director director firing directors disability services disciplined discounts discovery engine discovery market disease activity disease awareness disease clinical trials disease control rate disease drug disease flexibility disease program disease research disease sales disease therapies disease treatment disease vouchers disease-modifying treatment disorder control (procedure) disparagement dissolvable distributor network divestiture divestitures domestic pharmaceutical industry domestic production domestic supply chain doravirine doravirine/islatravir dose-response doubt downsides downsizing downturn draft report drinking levels drug activity drug ads drug affordability drug application drug approval outlook drug candidates drug collaboration drug combo drug competition drug conjugates drug delivery innovation drug delivery platform drug developability drug development pipeline drug development sentiment drug discontinuation drug discount program drug establishment registration drug failure drug import duties drug import plan drug importation drug imports drug ingredients drug lag drug launch drug licensing drug manufacturers drug markups drug optimization drug price discounts drug price negotiation drug prices fall abroad drug pricing plan drug pricing policy drug production drug quality drug rebates drug rejection letters drug rejections drug relabeling drug review reforms drug reviews drug sales drug supply chain drug trial setbacks drug-development candidates drug-device drug-resistant drug-resistant TB drug-resistant focal seizures drug-substance drug-to-data pivot drug-trial dual pathway inhibition dual-agonist dual-payload ADC dual-payload technology dual-targeting dulaglutide duplicate discounts dwarfism trial e-Lung e-posters eGenesis eRNA earlier-line treatment early disease early-phase trials early-stage trial earnings beat easing ecnoglutide efdoralprin alfa efimosfermin alfa efzofitimod egg-based elacestrant elebsiran electronic health record - ActClassContainer elenestinib elinzanetant elironrasib elranatamab emergency medicine (field) emiltatug ledadotin emotional dependency employee layoffs employment employment reduction emugrobart enLIGHTEN Discovery Platform end-to-end antibody discovery endocrine disease specialist endpoint selection enforcement action enforcement letters enfortumab enfortumab vedotin engasertib engineered peptides enlicitide decanoate enobosarm enrollment enrollment forms enrolment ensifentrine ensitrelvir entera enterprise reorganization environmental enzymatic enzyme engineering enzyme restoration enzyme technology eosinophil epigenetic immunomodifier epigenetic modulator epigenetic therapy epinephrine eplerenone equity buyback equity financing equity line equity upside ersodetug escape velocity esreboxetine estate estrogens etalanetug etanercept etrolizumab evaluation event cycle everolimus evidence-based exagamglogene autotemcel exclusivity extension executive actions executive changes executive compensation executive exits executive survey executive team executive vice president existential threats expanded label expansions expedited pathway experts booted expirations exploitation external control group external controls external partnerships extrahepatic RNAi eye disease trial eye treatment facilities facility closure facility consolidation factor XIIa factory closure fam-trastuzumab fantasy-romance farabursen farm-to-hospital faster fat loss fat reduction federal AI federal agencies federal courts federal directives federal grants federal workers fee structure fentanyl fesoterodine fibroblast immunology fibrodysplasia fibrosing fibrotic diseases fidrisertib field ablation figures filing checklist final analysis financial compliance financial guidance suspension financial outlook financial recovery financial strategy financial struggles financial troubles financing strategy findings aspects finerenone firi-cel firing first-half first-in-class antibiotic first-in-human trials first-line maintenance fiscal five-year flagship office flaws flu/COVID-19 foreclosure proceedings foreign companies foreign direct investment foreign drug manufacturing foreign factories foreign investment formula update formulary exclusion formulation viscosity formulations four-letter suffix franchise frataxin frataxin protein fratricide-resistant free trial frontline AML frontline therapy front‑line treatment fruit-flavored vapes full-year guidance full-year sales fulvestrant fumaric acid function functional testing funding agreement funding bill funding cut funding environment funding lapse funding round funding rounds fungal prophylaxis furosemide future-proofing gRED gallium gamma secretase inhibitor gamma-linolenic acid garadacimab-gxii garetosmab-grts gastric inhibitory polypeptide receptor gastroenteropancreatic neuroendocrine tumors gastrointestinal gemcitabine intravesical system gemcitabine releasing system gene delivery process gene editing trial gene editor gene modulation gene synthesis gene therapy platforms gene variants gene writing gene-editing therapy gene-silencing general-purpose generative generative design generative models generic competition generic manufacturing generic medications generic semaglutide generic tirzepatide generics revenue generics slump genetic cell genetic diagnosis genetic dilated cardiomyopathy genetic epilepsies genital lesion reduction genome engineering genome screening genomic analysis genomic drug discovery genomic medicines genomics AI genotoxicity geographic population geopolitical factors geopolitical risk glatiramer acetate global approval global commercialization global commercialization rights global competition global competitiveness global drug development global drug pipeline global growth strategy global headquarters global health programs global health security global license agreement global net sales global network global price global research collaboration global sales global strategic R&D center global strategic collaboration global strategic partnership global strategy global trade tensions global trial global workforce reduction glucose glycoengineering glycosylation go-to-market models golden decade golimumab golukibart government events government programs government review governmental engagement grace granite grant cancellation green energy green list green manufacturing gross profit growth Z-score growth drivers growth opportunities growth products guidance raise guidance revision guidance upgrade guidances gusacitinib hair loss treatment halt hand sensation hands-free harassment head-to-head psoriasis head-to-head trial headcount health coverage health data privacy health industry health information health officials health prediction health records health system partnerships health systems health tech venture health tracking health workers healthcare IPO healthcare IT healthcare agencies healthcare analytics healthcare appointments healthcare artificial intelligence healthcare benchmark healthcare budget healthcare changes healthcare data healthcare executive healthcare finance healthcare financial performance healthcare funding healthcare infrastructure healthcare innovation healthcare interoperability healthcare legislation healthcare marketing trends healthcare operational healthcare operations healthcare payments healthcare specialist healthcare startup healthcare trends healthcare venture healthcare workflow healthspan healthy lifespan healthy longevity heart drug heart events heart risk-benefit debate guidelines heavy drinking height velocity hematologic cancers hematologic care hematoxylin and eosin ( H&E ) stained hemophilia A program hep C pill hepatitis B functional cure hepatitis B policy change heroin herpesvirus 2, human heterozygous high-dose high-dose neurotherapy high-dose regimen high-performance computing high-profile high-risk patients high-throughput higher risk higher-value reagents highest-paid pharmaceutical CEOs hindrance hiring challenges hiring rebound histologic remission hold-and-kill homegrown hormone receptor-positive hospital apps hospital base hospital intervention hospital nutrition host disease hpDNA https://lnkd.in/gYKjeQ3n human care navigators human-relevant models huntingtin-lowering hyaluronidase hyaluronidase, human recombinant hybrid intelligence hydroxyurea hyper-personalized engagement hyperscaled data iMTP iNHL iPSC-derived iPSCs iSCIB1 + iSCIB1 + melanoma immunotherapy icatyde idiopathic Parkinson 's disease ifosfamide illegal immigration iloperidone iluzanebart image management imaging AI imaging biomarker immune compromise immune disorder therapy immune mapping immune profiling immune protection immune reset immune signaling pathways immune system reprogramming immune-based cancer cell therapies immune-related adverse events immuno-dermatology immuno-fibrosis immunocytokine immunoglobulin G immunology drug development immunotherapy drugs implantable device implementing import rules import taxes impression (attitude) impurity in situ in vivo studies in vivo therapy in-office incidents inclacumab incretin secretagogue incretin therapy indictment individual choice individual-based decision-making induction trials ineffective efforts infant infestation influenza prevention information session inhaled drugs inhaled lung disease inhaled therapies inidascamine initiation protocol injectable obesity therapy injectables innovate innovation centre innovation grants innovation pipeline innovation strategy innovative drugs innovative trial inorganic pyrophosphate inpatient insider insider trading insolvency insulin delivery insulin icodec-abae insulin production insulin resistance trends integrated decision-making integrated solutions interferon pathway interleukin-11 interleukin-23 receptor activity interleukin-3 interleukin-4 intermediate-risk internal disagreement internal rate internal tensions international drug international operations international pricing international reference pricing international trade internet phrase internship intestinal growth intisemeran intra-abdominal infections intracortical microstimulation intraoperative guidance intrathecal delivery intrathecal formulation intravenous delivery intravenous formula investigator-initiated trials investment cutback investment grants investor appetite investor reaction investor rescue investor scrutiny investor sentiment ion channel program ipsoprubart irAE isatuximab isolator technology issuance itolizumab itraconazole ixekizumab ixovec iza-bren izalontamab judgment jumping gene jumping genes juniper tar jurisdiction kickback scheme kidney drug kidney therapeutics kilobase pairs kinase inhibitor [EPC] kininogenase knockoffs kynurenic acid kyron.bio lab results label extension label update labeling change labeling changes laboratory modernization laboratory reform programme lack of lack of transparency lackluster data lanifibranor large-scale manufacture laru-zova late recurrence risk late-stage assets late-stage clinical development late-stage pipeline late-stage testing launch expenses launch sequencing lawmakers layoff leaders leadership shake-up league lean muscle lecanemab-irmb legacy cancer legacy operations legal concerns legal victory legality lenacapavir weekly lender takeover lentiviral vectors lenvatinib letrozole leuprolide levacetylleucine levodopa levosimendan levy liability frameworks license suspension licensing restrictions lidERA life science incubator life sciences companies life sciences fund life sciences real estate life-extension life-saving medicine likeability lincomycin linezolid liquidation live event liver enzyme elevation liver mRNA medicine liver survival loan financing localization locally advanced locally advanced head locally advanced risk long-acting injectable long-acting injectables long-acting protection long-acting therapies long-acting therapy longevity science lorlatinib loss of function loss treatment lotiglipron low low-cost lower dose lower-risk myelodysplastic syndromes lunbotinib fumarate lung scarring lunsekimig lupus skin drug lurbinectedin lymph nodes lymphocyte immune globulin, anti-thymocyte globulin lymphocyte-activation gene 3 protein lymphocyte-activation gene 3 protein, human mAbxience mCSPC mCombriax mFARS mFlusiva mGnP mHSPC mNEXSPIKE mRESVIA mRNA contracts mRNA degrader mRNA misinformation mRNA production mRNA therapy mRNA-1083 mRNA-1283 mRNA-1647 cytomegalovirus vaccine mRNA-4359 mRNA-based mRNA-based Personalized Cancer Vaccine mRNA-4157 mRNAs mTNBC mTORC1/2 inhibitor machine learning model macrocyclic drugs macroeconomic macrophage-based programmes macular maintenance phase malignancy risk malignant haematology management layers management technique mandates manifestation manufacturing challenges manufacturing closure manufacturing company manufacturing consolidation manufacturing jobs manufacturing license manufacturing organization manufacturing practice manufacturing problems manufacturing process manufacturing shutdown manufacturing uncertainty maridebart cafraglutide marketing approval marketing approval milestones marketing authorisation marketing officer marketplace marstacimab mast cell therapy match Eylea maternal-fetal monitoring mazdutide measles, mumps, rubella, varicella vaccine measurable outcomes mechanistic trials mechanoporation med-tech median employee medical advancements medical affairs reputation medical benchmarks medical breakthroughs medical data medical device company medical documentation AI medical freedom medical groups medical jargon medical leadership medical loss ratio medical review medical spas medical supplies medical supply chain medical technology exemptions medical wearables medical-device AI medtech industry meeting cancellation mega depots megadeal megascale melanin-concentrating hormone member membranoproliferative glomerulonephritis men 's health menen inhibitor mental health innovation mepolizumab merger cancellation merger termination mesothelin metabolic dysfunction-associated steatohepatitis metabolic medicines metagenomic sequencing metastasis-free metastatic solid tumors metastatic triple-negative breast cancer mezigdomide mezigitamab mice studies microcystic lymphatic malformations microdosing microneedle patches microneedles microparticle technology microservices mid-2030s mid-stage middle dose middle-income countries middlemen midline glioma midterm migraine prevention milestone payment milsaperidone mini-proteins miniPDX minimis exemption minimization miniprotein design suite mirror peptides missed doses missed milestone mitazalimab mivelsiran modular modular integrase platform molecular AI molecular design molecular entities molecular glue degrader molecular modalities molecular point-of-care molecular residual disease moments monogenic kidney diseases month most-favored motor fluctuations motor milestones mouse models movers mucosal healing multi-agent system multi-agent systems multi-agonists multi-cancer screening multi-cancer tests multi-domain proteins multi-institutional research multi-medicine platforms multi-modal multi-omic strategies multi-payload multi-program collaboration multi-sensor multi-specific antibodies multi-target collaboration multi-year collaboration multibillion-dollar market multiforme multimodal approach multimodal data multiple disease areas multiplex test multiport surgery multispecific antibody muscle disease therapy muscle health muscle loss muscle mass muscle strength endpoint muscle-invasive musculoskeletal conditions myQA StarTrack myelin repair myosin inhibitor myostatin antibody myostatin inhibitor nAMD nHCM naloxegol naltrexone-bupropion naming convention nano-in-micro delivery nanobody nanodelivery nanosecond naproxen-n-butyl nitrate narcolepsy drug narrow sales narsoplimab natalizumab nation policy national dementia registry national priorities national priority review voucher national priority review vouchers national sector growth nations natural orifice surgery naturalX nature-inspired drug discovery navacaprant navenibart navtemadlin needle-free vaccines negative adcomm negative opinion negotiators nemolizumab neo-epitope cancer vaccine neoantigen therapy neosubstrate neuro injury neuro pipeline neuro-metabolic diseases neuro-rare diseases neuro-specialty diseases neurobehavioral symptoms neurodegeneration therapy neurodegenerative neurofibroma neuroimmune disorders neuroinflammatory neurological therapies neuropathic corneal pain neuroplastogens neuroprotective neuropsychiatric disorders neuropsychiatric drugs neuroreparative therapeutics neuroscience division neuroscience portfolio neurotechnology neurovascular AI neutrophil-mediated disease new product newco nexiguran nexiguran ziclumeran next generation viral vectors next-gen brain therapies next-gen pneumonia next-generation Covid vaccine next-generation RNAi next-generation drugs next-generation vaccine nimodipine nintedanib ninth nipocalimab-aahu nirsevimab nizubaglustat nmHSPC nodularis nomination committee non-European ancestry non-FDA non-antipsychotic non-competitive profile non-cystic fibrosis bronchiectasis non-dilutive non-dilutive financing non-dilutive funding non-generic specialty non-hormonal therapy non-incretin therapies non-incretin therapy non-inferiority non-mRNA vaccine non-metastatic non-opioid non-opioid pain drug non-opioid pain medication non-opioid pain relief non-opioid pain therapies non-relapsing secondary progressive non-surgical back pain non-ultrasound-trained operators noncirrhotic nonclinical reporting nonprofit webinars nonrelapsing nonresponder nonsurgical treatment options normative wakefulness nucleic acid delivery nusinersen obesity pipeline obesity therapy obesity-related cancers obsidian ocadusertib ocular 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oral biologics oral carbapenem oral cholesterol pill oral drugs oral formulations oral hair loss oral inhibitors oral minoxidil oral obesity drug oral peptide oral pill oral pill vaccine oral presentation oral regimen oral small molecule RNA degrader oral small-molecule therapeutics oral small-molecule therapy oral targeted therapy oral weight loss drug orchestration orelabrtuinib orexin agonist orexin receptor type 2 organ donor organ fibrosis organ transplant rejection organic growth organizational simplification orglipron orphan drug exclusion orphan medicine orthopedic innovation osavampator ossificans otoferlin out-licensing outbound investment over-reaction overall response rate overhangs overhaul overhype overmedicalization overseas oversubscribed oversubscribed fund ownership increase ozekibart ozureprubart p-tau217 p53 reactivator pM category pTau217 packaging issues pain assets pain crises palivizumab pamirtecan pan-JAK inhibitor pan-KRAS pan-TEAD inhibitor pandemic influenza paradigm parent parental choice partial response partnering with pasritamig patent expiration patent license pathology AI patient definition patient enrollment patient intake patient management patient meals patient navigation patient populations patient recruitment patient-provider interaction patient-specific therapies patient-specific therapy patient-ventilator asynchrony patritumab pattern hair loss pause recommendation pay-for-delay payer paying payload payors peak sales pediatric brain cancer pediatric diseases pediatric dosage pediatric drug designation peer pelareorep penicillin recall pent-up demand peptide therapeutics performers perioperative therapy permanent role personal data personal genome service personalized cancer therapy personalized care personalized health services personalized healthcare personalized neuromodulation personalized treatment personnel change perspectives pertuzumab petition pharma TV ads pharma biggest company pharma brand engagement pharma 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requirement post-marketing studies postprandial povetacicept pozdeutinurad practice expense practice-changing pre-IPO pre-IPO ' pre-commercialization precision cardiology precision neurology preclinical CRO preclinical assets preclinical drug preclinical drug discovery preclinical pancreatic cancer preclinical program preclinical research preclinical studies preclinical testing pregnancy detection pregnancy screening preliminary assessment preliminary injunction premium hikes prescriber prescribers prescribing habits prescribing rules prescription drug ads prescription renewals prescription-drug prices prespecified pretomanid prevention antibody preventive healthcare preventive services panel price controls price decline price drop price hike price transparency price-fixing pricing flaw pricing information pricing policies pricing practices pricing pressures pricing reform prifemilast primary endpoints primary listing prion disease program prioritization priority brands priority 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monetization rubrics runway rural healthcare rusfertide PTG-300 sBLA sHTG sacituzumab govitecan sacituzumab govitecan-hziy safety signal salanersen sale rule sales guidance sales milestones sales outlook salicylhydroxamic acid sample stabilization satralizumab scFv scPharmaceuticals scSurvival scale-up scaling not solving scandal scenario school meals school vaccination science-led storytelling scientific advisors scientific discovery scientist protest screening platforms screening program search behavior seasonal flu seasonal influenza second quarter 2026 second-quarter secondary blood cancers secondary endpoint secondary markets secrecy China sector rotation secured secured debt securities fraud seed financing seed investments seizure drug seladelpar self-administered drug self-administration self-collection devices self-injectable self-injection business self-injection systems self-paying self-serve self-service selloff selpercatinib semax semiconductor supply chains semiconductor tariffs sensor (device) sentiment survey sequence-based AI serious breaches setrusumab sevasemten seventh shadow AI shakeup sham surgery sham-controlled trial shareholder value shelf registration statement shortage shot marketing shrinking shrinking budgets shutdowns shuttles siRNA therapy sialidase fusion protein sigma-2 receptor single-arm trial single-cell RNA sequencing single-digit royalties single-dose vials single-injection single-port surgery single-tablet single-use bioreactors sirolimus site closure site transfer size sizing kit skin clearance skin remission sleep biotech sleep-inducing peptide slow awareness slowdown slower small molecule agonists small molecule candidates small molecule design small molecule drug discovery small molecule drugs small molecule inhibitor small molecule inhibitors small molecule medicines small molecule therapies social disadvantage software-as-a-medical-device soles psoriasis solid cancers solid tumor cancer solid-state batteries soluble NSF attachment protein activity somatic genomics somato-cognitive action network somatropin sonefpeglutide sonesitatug sonrotoclax soquelitinib sorfequiline sortilin sotatercept-csrk spatial profiling spatial proteomics specialty brands specialty diseases specialty drugs specialty endocrinology spectral imaging spesolimab spin-out spine MRI spinoff spironolactone spleen exam splice correction splicing correction sponsors spotty complaint reporting staff exclusion staff reduction staff reorganization stage IV reduction stake sale stalking horse stalking-horse bidder stance standards characteristics starter dose statistical methods stealth stem cell-derived islet cells stem cell-secreted proteins stenoparib sterile cartridge facility sterile injectables sterile manufacturing steroid-sparing stock price stock purchase stock repurchase programs stock sale stock sales stock slide stock slip stockholder stockpile stockpiling stool imaging strain Big Pharma market pressures strain selection strategic advisory strategic alignment strategic alliance strategic assets strategic collaborations strategic decision-making strategic investors strategic options strategic overhaul strategic pivot strategic plan strategic reserves strategic transformation strategy streamlined process streamlined review streamlined system stroke trial structural changes stuttering pipeline subcutaneous administration subcutaneous elegrobart subcutaneously delivered antibodies sublingual tablets submission delays submission program submissions suboptimal response subscription cancellation success rates succession planning suicide suicide warnings sunitinib sunvozertinib superbugs supercomputer superiority trials superpotency supplemental approval supply chain exposure supply chain management supply chain resilience supply chains supply shortages supply suspension suppurativa supremacy surgical guidance surgical planning surgical robotics surrogacy surrogate endpoint surveillance aspects survival data survival extension survival hazard ratio survival rate sutacimig suvorexant sweat sensors synovial fibroblasts synthetic genomes synthetic royalty syphilis treatment taRNA tarcocimab tedromer target price target-effector pairs targeted alpha therapies targeted alpha therapy tariff avoidance tariff exemptions tariff increase tariff pause tariff threat tarlatamab-dlle tau therapy tau-targeted therapies tau-targeting tau-targeting antibody tau-targeting drug tavatecan team shutdown team transformation tebipenem tech partnerships technology innovation technology summits teen suicide telehealth platform tenofovir tenofovir disoproxil fumarate tenure terabytes terminated - RoleStatus tezepelumab therapeutic cancer therapeutic development therapeutic diversification therapeutic payloads therapist thermal imaging theta/beta ratio third quarter third-party facility three-year thrombotic disease thymic stromal lymphopoietin thymus regeneration thymus-targeted thymus-targeted therapy thyroid 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