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UPDATED: Kardigan buttons up $400M upsized IPO to power heart drugs toward phase 3

on June 18, 2026

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide Cardiovascular system IPO Kardigan Nasdaq KARD tonlamarsen

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Kardigan’s $320M IPO pitch: Three borrowed heart drugs, one proven cardio CEO

on June 12, 2026

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide Cardiovascular system IPO Kardigan methionine Myers Squibb MyoKardia Nasdaq KARD sanofi Tassos Gianakakos tonlamarsen

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Kardigan readies Nasdaq IPO to back three cardio drugs – latest news summary

on May 28, 2026

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide Cardiovascular Agents cardiovascular program diluted cardiomyopathy IPO KARD Kardigan Nasdaq tonlamarsen

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Kardigan files for IPO to fund late‑stage cardiovascular pipeline

on May 27, 2026

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide calcific aortic valve stenosis genetic dilated cardiomyopathy IPO Jefferies Kardigan Nasdaq KARD tonlamarsen

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"A Bit of a Surprise": Kardigan's Tonlamarsen Shows No Blood Pressure Benefit from Repeat Dosing in Phase 2 Trial

on March 30, 2026

Angiotensinogen Blood Pressure Hypertensive disease Kardigan KARDINAL trial Phase 2 tonlamarsen

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protocol concealment concerns safety concessions conditional approval pathway conditioning regimens confident confidentiality confirmation hearing confirmatory study confirmatory study failure conflict of conservative criticism conspiracy constitutional challenge constitutionality consumables consumer marketing consumer relationship content intelligence contextual errors contingent value continuous continuous trial contract cancellation contract extension contract manufacturer contract research controllable controlled-rate freezing controversy conversation conversational AI conversion factor convertible convertible loans cooperation copper histidinate copper isotopes core vaccines corn starch cornea surgeon corneal endothelial disease coronary imaging coronary trial corporate development cortisol modulator cost of care cost reduction cost-cutting initiatives cost-effective cost-effectiveness cost-effectiveness ratios cost-reduction cost-saving country-of-origin labeling covalent 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extension debt obligations decade-long safety test deceptive deceptive marketing decision day decision science declaratory judgment defactinib deficiencies degrader degree of relationship - exchange delayed readout delgocitinib delist delivery options demerger demyelination dencatistat depression drug deprioritization deputy commissioner deruxtecan-nxki deucrictibant XR developmental restoration device regulation dexmedetomidine diabetes drugs diagnostic kit diagnostics industry diazoxide choline difficult-to-treat psoriasis digestive health startup digital coaching digital cognitive assessments digital dermatology digital enablement digital endpoints digital health ecosystem digital health records digital health regulation digital health screener digital infrastructure digital marketing digital medicine digital microfluidics digital pathology prognostic test digital quality systems digital solutions digital therapeutic digital tools digital twin diluted cardiomyopathy 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etisparvovec etisparvovec-hopf etrolizumab evaluation event cycle everolimus evidence-based exagamglogene autotemcel exclusivity extension executive actions executive chair executive changes executive compensation executive exits executive survey executive team executive vice president existential threats expanded label expansions expedited pathway experts booted expirations exploitation external control group external controls external partnerships extrahepatic RNAi eye disease trial eye treatment facilities facility closure facility consolidation factor XIIa factory closure fam-trastuzumab fantasy-romance farabursen farm-to-hospital faster fat loss fat reduction federal AI federal agencies federal courts federal directives federal grants federal workers fee structure fentanyl fesoterodine fibroblast immunology fibrodysplasia fibrosing fibrotic diseases fidrisertib field ablation figures filing checklist final analysis financial compliance financial guidance suspension financial 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privacy health industry health information health officials health prediction health records health system partnerships health systems health tech venture health tracking health workers healthcare IPO healthcare IT healthcare agencies healthcare analytics healthcare appointments healthcare artificial intelligence healthcare benchmark healthcare budget healthcare changes healthcare data healthcare executive healthcare finance healthcare financial performance healthcare infrastructure healthcare innovation healthcare interoperability healthcare legislation healthcare marketing trends healthcare marketplace healthcare operational healthcare operations healthcare payments healthcare specialist healthcare spending healthcare startup healthcare startups healthcare trends healthcare venture healthcare workflow healthspan healthy lifespan healthy longevity heart drug heart events heart risk-benefit debate guidelines heavy drinking height velocity hematologic cancers hematologic care hematoxylin and eosin ( H&E ) stained hemophilia A program hep C pill hepatitis B functional cure hepatitis B policy change heroin herpesvirus 2, human heterozygous high-dose high-dose neurotherapy high-dose regimen high-performance computing high-profile high-risk patients high-throughput higher risk higher-value reagents highest-paid pharmaceutical CEOs hindrance hiring challenges hiring rebound histologic remission hold-and-kill homegrown hormone receptor-positive hospital apps hospital base hospital intervention hospital nutrition hospital operations host disease hpDNA https://lnkd.in/gYKjeQ3n human care navigators human-relevant models huntingtin-lowering hyaluronidase hyaluronidase, human recombinant hybrid intelligence hydroxyurea hyper-personalized engagement hyperscaled data iMTP iNHL iPSC-derived iPSCs iSCIB1 + iSCIB1 + melanoma immunotherapy icatyde idiopathic Parkinson 's disease ifosfamide illegal immigration iloperidone iluzanebart image management imaging AI imaging biomarker immune compromise immune disorder therapy immune mapping immune profiling immune protection immune reset immune signaling pathways immune system reprogramming immune-based cancer cell therapies immune-related adverse events immuno-dermatology immuno-fibrosis immunocytokine immunoglobulin G immunology drug development immunotherapy drugs implantable device implementing import rules import taxes impression (attitude) impurity in situ in vivo studies in vivo therapy in-office inaxaplin incidents inclacumab incretin secretagogue incretin therapy indictment individual choice individual-based decision-making induction trials ineffective efforts infant infestation influenza prevention information session inhaled drugs inhaled lung disease inhaled therapies inidascamine initiation protocol injectable obesity therapy injectables innovate innovation centre innovation grants innovation pipeline innovation strategy innovative drugs innovative trial inorganic pyrophosphate inpatient insider insider trading insolvency insulin delivery insulin efsitora insulin icodec-abae insulin production insulin resistance trends integrated decision-making integrated solutions interferon pathway interleukin-11 interleukin-23 receptor activity interleukin-3 interleukin-4 intermediate-risk internal disagreement internal rate internal tensions international drug international drug benchmarks international operations international pricing international reference pricing international trade internet phrase internship intestinal growth intisemeran intra-abdominal infections intracortical microstimulation intraoperative guidance intrathecal delivery intrathecal formulation intravenous delivery intravenous formula investigator-initiated trials investment cutback investment grants investor appetite investor reaction investor rescue investor scrutiny investor sentiment ion channel program irAE isatuximab isolator technology issuance itolizumab itraconazole ixekizumab ixovec iza-bren izalontamab judgment jumping gene jumping genes juniper tar jurisdiction jury kickback scheme kidney drug kidney therapeutics kilobase pairs kinase inhibitor [EPC] kininogenase knockoffs kynurenic acid kyron.bio lab results label extension label update labeling change labeling changes laboratory modernization laboratory reform programme lack of lack of transparency lackluster data lanifibranor large-scale manufacture laromestrocel late recurrence risk late-stage assets late-stage clinical development late-stage pipeline late-stage testing launch expenses launch sequencing lawmakers layoff leaders leadership shake-up league lean muscle lecanemab-irmb legacy cancer legacy operations legal concerns legal victory legality lenacapavir weekly lenalidomide lender takeover lentiviral vectors letrozole leuprolide levacetylleucine levodopa levosimendan levy liability frameworks license suspension licensing dispute licensing restrictions lidERA life science incubator life sciences companies life 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cytomegalovirus vaccine mRNA-4359 mRNA-based mRNA-based Personalized Cancer Vaccine mRNA-4157 mRNAs mTNBC mTORC1/2 inhibitor machine learning model macrocycles macrocyclic drugs macroeconomic macrophage-based programmes macular maintenance phase malignancy risk malignant haematology management layers management technique mandates manifestation manufacturing challenges manufacturing closure manufacturing company manufacturing consolidation manufacturing jobs manufacturing license manufacturing organization manufacturing practice manufacturing problems manufacturing process manufacturing shutdown manufacturing uncertainty maridebart cafraglutide marketing approval marketing approval milestones marketing authorisation marketing officer marketplace marstacimab mast cell therapy match Eylea maternal-fetal monitoring mazdutide measles, mumps, rubella, varicella vaccine measurable outcomes mechanistic trials mechanoporation med-tech median employee medical advancements medical affairs reputation medical benchmarks medical breakthroughs medical data medical device company medical documentation AI medical freedom medical groups medical jargon medical leadership medical loss ratio medical review medical spas medical supplies medical supply chain medical technology exemptions medical wearables medical-device AI medtech industry meeting cancellation mega depots megadeal megascale melanin-concentrating hormone member membranoproliferative glomerulonephritis men 's health menen inhibitor mental health innovation mepolizumab merger cancellation merger termination mesothelin metabolic dysfunction-associated steatohepatitis metabolic medicines metagenomic sequencing metastasis-free metastatic solid tumors metastatic triple-negative breast cancer mezigdomide mezigitamab mice studies microcystic lymphatic malformations microdosing microneedle patches microneedles microparticle technology microservices mid-2030s mid-stage middle dose middle-income countries middlemen midline 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paying payload payors peak sales pediatric brain cancer pediatric diseases pediatric dosage pediatric drug designation peer pelareorep penicillin recall pent-up demand peptide therapeutics peptide therapy performers perioperative therapy permanent role personal data personal genome service personalized cancer therapy personalized care personalized health services personalized healthcare personalized neuromodulation personalized treatment personnel change perspectives pertuzumab petition pharma TV ads pharma biggest company pharma brand engagement pharma companies pharma consolidation pharma directors pharma division pharma industry pharma investment pharma investments pharma marketing pharma packaging pharma patent expirations pharma policy pharma reforms pharma reshoring pharma response pharma silos pharma skills shortage pharma tech pharma trade group pharmaceutical AI pharmaceutical advertising crackdown pharmaceutical backing pharmaceutical collaboration pharmaceutical communications pharmaceutical delays pharmaceutical delivery pharmaceutical divestment pharmaceutical drug discount resistance pharmaceutical earnings pharmaceutical employment pharmaceutical imports pharmaceutical investment pharmaceutical investment Germany pharmaceutical lawsuits pharmaceutical leadership pharmaceutical licensing pharmaceutical lobby pharmaceutical market pharmaceutical megadeal pharmaceutical mergers pharmaceutical milestones pharmaceutical processing pharmaceutical rebates pharmaceutical revenue pharmaceutical sector pharmaceutical setback pharmaceutical setbacks pharmaceutical survey pharmaceutical trade pharmaceutical trade war pharmacy platform pharmacy reimbursement phase 2/3 trial phase 3 POIESIS trial phase 3 failure philanthropy phosphodiesterase 4B phosphorylated physiologic rate physiological aspects physiological chemistry pilot data pimecrolimus pipeline blips pipeline cull pipeline disruptions pipeline gaps pipeline management pipeline restructuring pipeline setbacks pipeline shake-up pipeline shift pipeline update pipeline work pivekimab sunirine pivot resources pivoxil pizuglanstat placebo-adjusted efficacy placebo-adjusted improvement plant construction plasma-derived therapies plasma-derived therapy platelet levels platform immunotherapy * * pledge plozasiran pneumococcal conjugate vaccines pociredir podcast political politicization poly-refractory rheumatoid arthritis portfolio companies portfolio prioritization portfolio reprioritization portfolio support porustobart posdinemab post-COVID post-hoc analysis post-marketing requirement post-marketing studies post-thaw viability postprandial povetacicept pozdeutinurad practice expense practice-changing pre-IPO pre-IPO ' pre-commercialization pre-seed funding precision cardiology precision neurology preclinical CRO preclinical assets preclinical drug preclinical drug discovery preclinical pancreatic cancer preclinical program preclinical studies preclinical testing pregnancy detection pregnancy screening preliminary assessment preliminary injunction premium hikes prescriber prescribers prescribing habits prescribing rules prescription drug ads prescription renewals prescription-drug prices prespecified pretomanid prevention antibody preventive healthcare preventive services panel price controls price decline price drop price hike price transparency price-fixing pricing flaw pricing information pricing policies pricing practices pricing pressures pricing reform prifemilast primary endpoints primary listing princeton prion disease program prioritization priority brands priority vouchers private block trade private placement financing proactive care producer cell lines product hopping product strategy production relocation professional development profit profit margin profit-sharing programmable RNA medicines programmable biology progressiva project cancellation proof-of-concept study propane propiolactone proprietary data protections protein AI protein compounds protein drug discovery protein elimination therapeutics protein expression protein expression platform protein folding protein levels protein science protein structures protein-based vaccine protein-ligand datasets protein-ligand prediction provider operations provider training provisional patent prula-cel pruritus chronic pruritus treatment pseudobulbar psychedelic biotech psychedelic medicines psychedelic mental health market psychedelic supply psychedelics guidance psychiatric trials psychiatry pipeline public biotech public companies public company public fund public health agencies

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