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Federated AI Advances in Binding Affinity and ADMET Prediction for Drug Discovery

Apheris launched the ADMET Network, a federated learning platform uniting pharma companies like Lundbeck, Orion Pharma, Recursion, and Servier to train privacy-preserving AI models for ADMET predictions using 80% of their proprietary data. 1 SandboxAQ released AQAffinity on January 20, 2026, a structure-free binding affinity prediction model built on OpenFold3, enabling rapid evaluation of drug candidates without experimental structures. 2 The OpenFold Consortium, involving Apheris collaborations with AbbVie, J&J, and others, fine-tunes OpenFold3 for protein-ligand interactions in a confidential environment. 1 2 2026 predictions highlight maturing protein structure and binding affinity prediction models, though they require hybrid AI-physics approaches for drug discovery success. 3 Sources: 1. https://www.genengnews.com/topics/artificial-intelligence/admet-predictions-get-ai-boost-federated-data-network-unites-pharma/ 2. https://www.prnewswire.com/news-releases/sandboxa...

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