MindWalk Announces B Cell Llama, a Nanobody Discovery Platform Designed for the Bispecific and Cell Therapy Era

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MindWalk Holdings Corp. (NASDAQ:
HYFT) announced B Cell Llama, a platform for discovering VHH nanobodies, which are single-domain antibody fragments used as building blocks for bispecific antibodies, multispecific therapeutics, and CAR-T cell therapies13

The platform extends MindWalk's existing B Cell Select infrastructure by isolating antibody-producing B cells from immunized llamas rather than rabbits, capturing VHH nanobodies from naturally matured immune repertoires13

A peer-reviewed study published in Biomacromolecules (American Chemical Society, 2026) demonstrated that multivalent VHH formats achieved sub-nanomolar potency 10 to 25 times greater than monovalent formats, and that modular VHH constructs could neutralize variants resistant to monovalent formats and approved antibody therapies13

The platform uses MindWalk's LensAI technology across the entire discovery process, from immunogen design through candidate selection and multispecific construct modeling, prioritizing functional efficacy over binding affinity15

Bispecific antibody sales are projected to reach US$50 billion by 2030, with the broader cell therapy market contributing tens of billions more13

MindWalk has secured exclusive rights to commercialize intellectual property developed through collaboration with Eindhoven University of Technology and Radboud University Medical Center, which received backing from Health Holland via the Eureka Program2

Sources:

1. https://www.stocktitan.net/news/HYFT/mind-walk-announces-b-cell-llama-tm-a-nanobody-discovery-platform-759vh7doavzl.html

2. https://www.streetinsider.com/Corporate+News/MindWalk+launches+B+Cell+Llama+nanobody+discovery+platform/26125226.html

3. https://www.businesswire.com/news/home/20260306778890/en/MindWalk-Announces-B-Cell-Llama-a-Nanobody-Discovery-Platform-Designed-for-the-Bispecific-and-Cell-Therapy-Era

5. https://www.gurufocus.com/news/8686265/mindwalk-hyft-introduces-b-cell-llama-for-enhanced-antibody-discovery