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on June 24, 2026

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key drug from Pfizer's $43B Seagen acquisition failed a pivotal Phase 3 lung cancer trial; Pfizer's antibody-drug conjugate sigvotatug vedotin did not significantly improve overall survival versus docetaxel in previously treated non-squamous NSCLC; failure raises concerns about the near‑term value of Seagen assets and complicates Pfizer's oncology strategy.

Sources:

Pfizer's first new ADC from Seagen buy fails ph. 3 NSCLC trial

Closely watched Pfizer lung cancer drug falls short in clinical trial

Pfizer Deepens Bet on ADCs - ADC Summit 2026

Pfizer drug acquired in Seagen deal disappoints in lung cancer study

辉瑞肺癌疗法遇挫未伤根本但其价值430亿美元的Seagen相关预期进一步降温

sigvotatug vedotin (PF-08046047) / Pfizer - LARVOL DELTA

Pfizer ADC, from Seagen M&A, fails in phase III NSCLC trial | BioWorld

Pfizer Terminates PF-08046032 Phase I Trial - AllSci

Pfizer's Experimental Lung Cancer Drug Fails to Boost Survival

[PDF] Generation Pipeline at ASCO 2026 - View PDF

Pfizer lung cancer drug fails in late-stage trial (PFE:NYSE)

Pfizer's PD-L1 ADC is First to Enter Phase III PharmCube-News ...

Pfizer $43B Seagen Acquisition Pipeline Weakens After Lung ...

Pfizer (PFE) Lung Cancer Drug Misses Survival Goal In Phase 3 Trial

Clinical Trial for Advanced Non-Small Cell Lung Cancer, Non-Small ...

Be6A docetaxel Keytruda Lung-01 Malignant neoplasm of lung Neoplasms Non-Small Cell Lung Carcinoma Overall Survival Pfizer Phase 3 trial Seagen SigVie-002 sigvotatug vedotin therapeutic autologous dendritic cells

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