Researchers at Icahn School of Medicine at Mount Sinai used AI with reinforcement learning to generate compounds inhibiting kappa-opioid receptors (KOR), potentially alleviating opioid withdrawal and cravings.5
KOR inhibition is promising for treating opioid dependence by addressing brain reward rewiring and withdrawal symptoms after chronic opioid exposure.5
AI model trained on KOR and known drug data produced promising compounds for synthesis, cell testing, and future animal model evaluation for safety and efficacy.5
Presentations occurred at the 67th Annual Biophysical Society Meeting in February, highlighting AI's role in accelerating anti-addiction drug discovery.5
Sources:
5. https://www.biophysics.org/news-room/how-ai-can-help-design-drugs-to-treat-opioid-addiction